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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
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1961 3
1962 2
1963 1
1964 1
1965 1
1966 1
1968 3
1970 3
1971 2
1972 2
1973 5
1974 1
1975 1
1976 6
1977 3
1978 1
1980 2
1982 1
1983 8
1984 3
1985 2
1986 2
1987 1
1988 6
1989 1
1990 4
1991 5
1992 2
1993 1
1994 7
1995 7
1996 14
1997 8
1998 6
1999 25
2000 22
2001 28
2002 26
2003 39
2004 28
2005 43
2006 45
2007 46
2008 79
2009 81
2010 103
2011 113
2012 132
2013 135
2014 157
2015 139
2016 135
2017 105
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2019 135
2020 136
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2022 146
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2024 71

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2,320 results

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Page 1
Indole and Indoline Scaffolds in Antimicrobials: Overview, Synthesis and Recent Advances in Antimicrobial Research.
Nieto MJ, Lupton HK. Nieto MJ, et al. Curr Med Chem. 2021;28(24):4828-4844. doi: 10.2174/0929867327666201102114923. Curr Med Chem. 2021. PMID: 33138747 Review.
The indoline is a scaffold with significantly less historical studies and FDA-approved drugs and it has attracted new interest in drug design and development. In recent years, indoline-containing compounds have been shown to have antibacterial activity as well as ac …
The indoline is a scaffold with significantly less historical studies and FDA-approved drugs and it has attracted new interest in dru …
Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity.
Fritschi CJ, Anang S, Gong Z, Mohammadi M, Richard J, Bourassa C, Severino KT, Richter H, Yang D, Chen HC, Chiu TJ, Seaman MS, Madani N, Abrams C, Finzi A, Hendrickson WA, Sodroski JG, Smith AB 3rd. Fritschi CJ, et al. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2222073120. doi: 10.1073/pnas.2222073120. Epub 2023 Mar 24. Proc Natl Acad Sci U S A. 2023. PMID: 36961924 Free PMC article.
Viruses that were selected for resistance to the lead indane CD4mc, BNM-III-170, are susceptible to inhibition by the indoline CD4mcs. The indoline CD4mcs also potently sensitize HIV-1-infected cells to ADCC mediated by plasma from HIV-1-infected individuals. Crysta …
Viruses that were selected for resistance to the lead indane CD4mc, BNM-III-170, are susceptible to inhibition by the indoline CD4mcs …
Discovery of indoline-based derivatives as effective ROCK2 inhibitors for the potential new treatment of idiopathic pulmonary fibrosis.
Fu S, Wen Y, Peng B, Tang M, Shi M, Liu J, Yang Y, Si W, Guo Y, Li X, Yan T, Kang J, Pei H, Chen L. Fu S, et al. Bioorg Chem. 2023 Aug;137:106539. doi: 10.1016/j.bioorg.2023.106539. Epub 2023 Apr 20. Bioorg Chem. 2023. PMID: 37163811
Herein, a new series of selective ROCK2 inhibitors based on indoline were designed and synthesized. Structural modification resulted in optimized compound 9b with an IC(50) value of 6 nM against ROCK2 and the inhibition of collagen gel contraction. ...
Herein, a new series of selective ROCK2 inhibitors based on indoline were designed and synthesized. Structural modification resulted …
Water Modulated Diastereoselective Synthesis of cis/trans-Spiro[indoline-3,6'-naphtho[2,3-c]carbazoles].
Yan C, Sun J, Han Y, Yan CG. Yan C, et al. J Org Chem. 2021 Jul 16;86(14):9263-9279. doi: 10.1021/acs.joc.1c00044. Epub 2021 Jul 1. J Org Chem. 2021. PMID: 34197117
The reaction with the hydrated p-TsOH afforded trans-isomers of dihydrospiro[indoline-3,6'-naphtho[2,3-c]carbazoles] as major products. Alternatively, the reaction with anhydrous p-TsOH under a Dean and Stark apparatus predominately gave cis-isomer of dihydrospiro[indol …
The reaction with the hydrated p-TsOH afforded trans-isomers of dihydrospiro[indoline-3,6'-naphtho[2,3-c]carbazoles] as major product …
Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions.
Zhou Y, Piergentili I, Hong J, van der Helm MP, Macchione M, Li Y, Eelkema R, Luo S. Zhou Y, et al. Org Lett. 2020 Aug 7;22(15):6035-6040. doi: 10.1021/acs.orglett.0c02128. Epub 2020 Jul 29. Org Lett. 2020. PMID: 32790427
However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion intermedi …
However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating g …
SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors.
Yu W, Deng Y, Hopkins B, Huang X, Sloman D, Zhang H, Li D, McGowan MA, White C, Pu Q, Liu K, Fradera X, Lesburg CA, Martinot T, Doty A, Ferguson H, Nickbarg EB, Cheng M, Geda P, Song X, Smotrov N, Abeywickrema P, Andrews C, Chamberlin C, Mabrouk O, Curran P, Richards M, Saradjian P, Miller JR, Knemeyer I, Otte K, Vincent S, Sciammetta N, Bennett DJ, Han Y. Yu W, et al. Bioorg Med Chem Lett. 2021 Sep 1;47:128214. doi: 10.1016/j.bmcl.2021.128214. Epub 2021 Jun 21. Bioorg Med Chem Lett. 2021. PMID: 34166782
A novel series of IDO1 inhibitors have been identified with good IDO1 Hela cell and human whole blood activity. These inhibitors contain an indoline or a 3-azaindoline scaffold. Their structure-activity-relationship studies have been explored. ...
A novel series of IDO1 inhibitors have been identified with good IDO1 Hela cell and human whole blood activity. These inhibitors contain an …
Recent Advances in Metal-catalyzed Alkylation, Alkenylation and Alkynylation of Indole/indoline Benzenoid Nucleus.
Pradhan S, De PB, Shah TA, Punniyamurthy T. Pradhan S, et al. Chem Asian J. 2020 Dec 14;15(24):4184-4198. doi: 10.1002/asia.202001159. Epub 2020 Nov 23. Chem Asian J. 2020. PMID: 33164333 Review.
Selective editing of the benzenoid C-H bonds (C4-C7) in indoles/indolines has received great interest because functionalized indoles/indolines are featured in many marketed drugs and natural products. ...This review covers the recent advances in selective C-C bond f …
Selective editing of the benzenoid C-H bonds (C4-C7) in indoles/indolines has received great interest because functionalized indoles/ …
Increased antibacterial properties of indoline-derived phenolic Mannich bases.
Rimpiläinen T, Nunes A, Calado R, Fernandes AS, Andrade J, Ntungwe E, Spengler G, Szemerédi N, Rodrigues J, Gomes JP, Rijo P, Candeias NR. Rimpiläinen T, et al. Eur J Med Chem. 2021 Aug 5;220:113459. doi: 10.1016/j.ejmech.2021.113459. Epub 2021 Apr 20. Eur J Med Chem. 2021. PMID: 33915373
The search for antibacterial agents for the combat of nosocomial infections is a timely problem, as antibiotic-resistant bacteria continue to thrive. The effect of indoline substituents on the antibacterial properties of aminoalkylphenols was studied, leading to the develo …
The search for antibacterial agents for the combat of nosocomial infections is a timely problem, as antibiotic-resistant bacteria continue t …
Asymmetric Synthesis of Spiro[Azetidine-3,3'-Indoline]-2,2'-Diones via Copper(I)-Catalyzed Kinugasa/C-C Coupling Cascade Reaction.
Zhong X, Huang M, Xiong H, Liang Y, Zhou W, Cai Q. Zhong X, et al. Angew Chem Int Ed Engl. 2022 Oct 17;61(42):e202208323. doi: 10.1002/anie.202208323. Epub 2022 Sep 19. Angew Chem Int Ed Engl. 2022. PMID: 36053546
Spiro[azetidine-indolines] are important scaffolds in diverse bioactive compounds. Current efforts to synthesize spiro[azetidine-indolines] are limited to chiral spiro[azetidine-2,3'-indolines]. Asymmetric synthesis of structurally similar chiral spiro[azetid …
Spiro[azetidine-indolines] are important scaffolds in diverse bioactive compounds. Current efforts to synthesize spiro[azetidine-i …
Asymmetric Synthesis of Indoline from Achiral Phthalimide Involving Crystallization-Induced Deracemization.
Nakamura T, Ban K, Yoshida Y, Mino T, Kasashima Y, Sakamoto M. Nakamura T, et al. Chemistry. 2021 Nov 25;27(66):16338-16341. doi: 10.1002/chem.202103345. Epub 2021 Oct 8. Chemistry. 2021. PMID: 34585795
Crystallization-induced dynamic deracemization by Viedma ripening from racemic indoline was performed with an excellent enantioselectivity of 99 % ee. Furthermore, one-pot asymmetric synthesis of the indoline was achieved by the photochemical reaction of achiral pht …
Crystallization-induced dynamic deracemization by Viedma ripening from racemic indoline was performed with an excellent enantioselect …
2,320 results